Journal of Pathology Informatics Journal of Pathology Informatics
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ORIGINAL ARTICLE
Year : 2020  |  Volume : 11  |  Issue : 1  |  Page : 4

Artificial intelligence-driven structurization of diagnostic information in free-text pathology reports


1 Institute for Data Science and Informatics, University of Missouri, Columbia, MO 65211; Department of Pathology and Anatomical Sciences, School of Medicine, University of Missouri, Columbia, MO 65212, United States
2 Institute for Data Science and Informatics, University of Missouri, Columbia, MO 65211, United States; Department of Computer Science, College of Science for Women, University of Baghdad, Baghdad, Iraq
3 Department of Pathology and Anatomical Sciences, School of Medicine, University of Missouri, Columbia, MO 65212, United States
4 Institute for Data Science and Informatics, University of Missouri, Columbia, MO 65211, United States
5 Department of Health Management and Informatics, School of Medicine, University of Missouri, Columbia, MO 65212; Institute for Data Science and Informatics, University of Missouri, Columbia, MO 65211; Department of Electrical Engineering and Computer Science, College of Engineering, University of Missouri, Columbia, MO 65211, United States
6 Institute for Data Science and Informatics; Department of Electrical Engineering and Computer Science, College of Engineering, University of Missouri, Columbia, MO 65211, United States
7 Department of Electrical Engineering and Computer Science, College of Engineering; Institute for Data Science and Informatics, University of Missouri, Columbia, MO 65211, United States
8 Department of Pathology and Anatomical Sciences, School of Medicine, University of Missouri, Columbia, MO 65212; Institute for Data Science and Informatics, University of Missouri, Columbia, MO 65211, United States
9 Department of Pathology and Anatomical Sciences, School of Medicine, University of Missouri, Columbia, MO 65212; Institute for Data Science and Informatics; Department of Electrical Engineering and Computer Science, College of Engineering, University of Missouri, Columbia, MO 65211, United States

Correspondence Address:
Dr. Dmitriy Shin
Department of Pathology and Anatomical Sciences, School of Medicine, University of Missouri, Columbia, MO 65212
United States
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jpi.jpi_30_19

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Background: Free-text sections of pathology reports contain the most important information from a diagnostic standpoint. However, this information is largely underutilized for computer-based analytics. The vast majority of NLP-based methods lack a capacity to accurately extract complex diagnostic entities and relationships among them as well as to provide an adequate knowledge representation for downstream data-mining applications. Methods: In this paper, we introduce a novel informatics pipeline that extends open information extraction (openIE) techniques with artificial intelligence (AI) based modeling to extract and transform complex diagnostic entities and relationships among them into Knowledge Graphs (KGs) of relational triples (RTs). Results: Evaluation studies have demonstrated that the pipeline's output significantly differs from a random process. The semantic similarity with original reports is high (Mean Weighted Overlap of 0.83). The precision and recall of extracted RTs based on experts' assessment were 0.925 and 0.841 respectively (P <0.0001). Inter-rater agreement was significant at 93.6% and inter-rated reliability was 81.8%. Conclusion: The results demonstrated important properties of the pipeline such as high accuracy, minimality and adequate knowledge representation. Therefore, we conclude that the pipeline can be used in various downstream data-mining applications to assist diagnostic medicine.


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