Journal of Pathology Informatics

ORIGINAL ARTICLE
Year
: 2018  |  Volume : 9  |  Issue : 1  |  Page : 37-

Implementing the DICOM standard for digital pathology


Markus D Herrmann1, David A Clunie2, Andriy Fedorov3, Sean W Doyle1, Steven Pieper4, Veronica Klepeis5, Long P Le5, George L Mutter6, David S Milstone6, Thomas J Schultz7, Ron Kikinis3, Gopal K Kotecha1, David H Hwang6, Katherine P Andriole8, A John Iafrate5, James A Brink9, Giles W Boland11, Keith J Dreyer10, Mark Michalski10, Jeffrey A Golden6, David N Louis5, Jochen K Lennerz5 
1 MGH and BWH Center for Clinical Data Science, Boston, MA, USA
2 PixelMed Publishing, LLC, Bangor, PA, USA
3 Department of Radiology, Surgical Planning Laboratory, Brigham and Women's Hospital; Harvard Medical School, Boston, MA, USA
4 Isomics, Inc., Cambridge, MA, USA
5 Harvard Medical School; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
6 Harvard Medical School; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA
7 Enterprise Medical Imaging, Massachusetts General Hospital, Boston, MA, USA
8 MGH and BWH Center for Clinical Data Science; Harvard Medical School; Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA
9 Harvard Medical School; Department of Radiology, Massachusetts General Hospital, Boston, MA, USA
10 MGH and BWH Center for Clinical Data Science; Harvard Medical School; Department of Radiology, Massachusetts General Hospital, Boston, MA, USA

Correspondence Address:
Jochen K Lennerz
Department of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, GRJ 1015, Boston, MA 02114
USA

Background: Digital Imaging and Communications in Medicine (DICOM®) is the standard for the representation, storage, and communication of medical images and related information. A DICOM file format and communication protocol for pathology have been defined; however, adoption by vendors and in the field is pending. Here, we implemented the essential aspects of the standard and assessed its capabilities and limitations in a multisite, multivendor healthcare network. Methods: We selected relevant DICOM attributes, developed a program that extracts pixel data and pixel-related metadata, integrated patient and specimen-related metadata, populated and encoded DICOM attributes, and stored DICOM files. We generated the files using image data from four vendor-specific image file formats and clinical metadata from two departments with different laboratory information systems. We validated the generated DICOM files using recognized DICOM validation tools and measured encoding, storage, and access efficiency for three image compression methods. Finally, we evaluated storing, querying, and retrieving data over the web using existing DICOM archive software. Results: Whole slide image data can be encoded together with relevant patient and specimen-related metadata as DICOM objects. These objects can be accessed efficiently from files or through RESTful web services using existing software implementations. Performance measurements show that the choice of image compression method has a major impact on data access efficiency. For lossy compression, JPEG achieves the fastest compression/decompression rates. For lossless compression, JPEG-LS significantly outperforms JPEG 2000 with respect to data encoding and decoding speed. Conclusion: Implementation of DICOM allows efficient access to image data as well as associated metadata. By leveraging a wealth of existing infrastructure solutions, the use of DICOM facilitates enterprise integration and data exchange for digital pathology.


How to cite this article:
Herrmann MD, Clunie DA, Fedorov A, Doyle SW, Pieper S, Klepeis V, Le LP, Mutter GL, Milstone DS, Schultz TJ, Kikinis R, Kotecha GK, Hwang DH, Andriole KP, Iafrate A J, Brink JA, Boland GW, Dreyer KJ, Michalski M, Golden JA, Louis DN, Lennerz JK. Implementing the DICOM standard for digital pathology.J Pathol Inform 2018;9:37-37


How to cite this URL:
Herrmann MD, Clunie DA, Fedorov A, Doyle SW, Pieper S, Klepeis V, Le LP, Mutter GL, Milstone DS, Schultz TJ, Kikinis R, Kotecha GK, Hwang DH, Andriole KP, Iafrate A J, Brink JA, Boland GW, Dreyer KJ, Michalski M, Golden JA, Louis DN, Lennerz JK. Implementing the DICOM standard for digital pathology. J Pathol Inform [serial online] 2018 [cited 2019 Dec 16 ];9:37-37
Available from: http://www.jpathinformatics.org/article.asp?issn=2153-3539;year=2018;volume=9;issue=1;spage=37;epage=37;aulast=Herrmann;type=0