Close
  Indian J Med Microbiol
 

Figure 5: Examples of tumor associated collagen signatures (TACS - 3) positive and negative regions within our cohort of breast cancer samples. Collagen fibers (yellow) registered and overlaid onto bright field images of an H&E stained tissues. These images illustrate the features of the TACS - 3 signature (green arrows, top row), particularly, straightened aligned collagen fibers that terminate at steep angles relative to epithelial region boundaries (a - c). Three TACS - 3 negative cases are shown for comparison (red arrows, bottom row), where collagen fibers are wavy (d), terminate at adipose tissue (e), and wrap around epithelium (f) scale bar = 25 μm

Figure 5: Examples of tumor associated collagen signatures (TACS - 3) positive and negative regions within our cohort of breast cancer samples. Collagen fibers (yellow) registered and overlaid onto bright field images of an H&E stained tissues. These images illustrate the features of the TACS - 3 signature (green arrows, top row), particularly, straightened aligned collagen fibers that terminate at steep angles relative to epithelial region boundaries (a - c). Three TACS - 3 negative cases are shown for comparison (red arrows, bottom row), where collagen fibers are wavy (d), terminate at adipose tissue (e), and wrap around epithelium (f) scale bar = 25 μm