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  Indian J Med Microbiol
 

Figure 3: Diagnostic decision support graphics provide topography and count metrics for tissue hotspots. Automated mapping of the tissue grid tiles having the most numerous mitotic figure counts across the entire tissue section image is illustrated in the context of the image processing tile grid. Each tile area (2.29 mm2) is commensurate with ten high-power (×40) fields of view on standard clinical microscopes (2.37 mm2 area). (a) Square tiles h1–h5, assigned by the automated topometric mitotic hot spot tool, represent the five tiles with the highest mitotic figure count. In context of the grid regions of interest, the hot spot tiles reveal the topographic heterogeneity of the proliferative activity in this example tumor. The square (red box) depicts the h1 tile with the highest mitotic figure count. (b) Mitotic figure count values are plotted for up to 100 tiles having the greatest counts, providing an indication of the proliferative characteristics across a tissue section. The graphic depicts plots for 30 biopsies. The inset graphic depicts the relative differences in proliferative characteristics within the 50 highest count tiles of 27 tumor specimens. The three most proliferatively active melanoma cases were excluded for illustration purposes

Figure 3: Diagnostic decision support graphics provide topography and count metrics for tissue hotspots. Automated mapping of the tissue grid tiles having the most numerous mitotic figure counts across the entire tissue section image is illustrated in the context of the image processing tile grid. Each tile area (2.29 mm<sup>2</sup>) is commensurate with ten high-power (×40) fields of view on standard clinical microscopes (2.37 mm<sup>2</sup> area). (a) Square tiles h1–h5, assigned by the automated topometric mitotic hot spot tool, represent the five tiles with the highest mitotic figure count. In context of the grid regions of interest, the hot spot tiles reveal the topographic heterogeneity of the proliferative activity in this example tumor. The square (red box) depicts the h1 tile with the highest mitotic figure count. (b) Mitotic figure count values are plotted for up to 100 tiles having the greatest counts, providing an indication of the proliferative characteristics across a tissue section. The graphic depicts plots for 30 biopsies. The inset graphic depicts the relative differences in proliferative characteristics within the 50 highest count tiles of 27 tumor specimens. The three most proliferatively active melanoma cases were excluded for illustration purposes