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  Indian J Med Microbiol
 

Figure 4: Performance fit comparisons between the automated topometric mitotic figure hotspot tool (TMHS) and mitotic figure quantification by expert visual assessment or a second machine object counting algorithm (OCA). Regression scatter plots of paired mitotic figure count observations (log10) from the TMHS h1 hot spot, with (a) counts independently obtained by pathologist (R1 hotspot), (b) counts of the automated h1-selected topometric hotspot obtained by the pathologist, or (c) counts from the automated h1-selected topometric hotspot obtained by object counting algorithm counting. Two data points deviating from the regression line were noted in particular. One of these cases displayed in c was influenced by a weaker immunohistochemistry signal development (lower point, ID 3043). In the second case (upper point, ID 4583), repeat counts obtained by the pathologist ranged from 14 to 16 for both h1 and R1 hotspots, which were regions of interest completely overlapping topographically. Blue-shaded areas represent 95% confidence intervals. R2 values and regression equations are indicated on the figure. All comparisons represented significant correlations

Figure 4: Performance fit comparisons between the automated topometric mitotic figure hotspot tool (TMHS) and mitotic figure quantification by expert visual assessment or a second machine object counting algorithm (OCA). Regression scatter plots of paired mitotic figure count observations (log<sub>10</sub>) from the TMHS h1 hot spot, with (a) counts independently obtained by pathologist (R1 hotspot), (b) counts of the automated h1-selected topometric hotspot obtained by the pathologist, or (c) counts from the automated h1-selected topometric hotspot obtained by object counting algorithm counting. Two data points deviating from the regression line were noted in particular. One of these cases displayed in c was influenced by a weaker immunohistochemistry signal development (lower point, ID 3043). In the second case (upper point, ID 4583), repeat counts obtained by the pathologist ranged from 14 to 16 for both h1 and R1 hotspots, which were regions of interest completely overlapping topographically. Blue-shaded areas represent 95% confidence intervals. <i>R</i><sup>2</sup> values and regression equations are indicated on the figure. All comparisons represented significant correlations