Computer-aided laser dissection: A microdissection workflow leveraging image analysis tools

Jason D Hipp¹, Donald J Johann², Yun Chen³, Anant Madabhushi⁴, James Monaco⁵, Jerome Cheng⁶, Jaime Rodriguez-Canales⁷, Martin C Stumpe⁸, Greg Riedlinger⁹, Avi Z Rosenberg¹⁰, Jeffrey C Hanson¹¹, Lakshmi P Kunju⁶, Michael R Emmert-Buck¹², Ulysses J Balis⁶, Michael A Tangrea^13
1 Laboratory of Pathology, National Cancer Institute, Bethesda, MD; Google Inc., Mountain View, CA, USA
² Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA
³ Laboratory of Pathology, National Cancer Institute, Bethesda, MD; Department of Mechanical Engineering, Johns Hopkins University, Baltimore, MD, USA
⁴ Department of Biomedical Engineering, Center for Computational Imaging and Personalized Diagnostics, Case Western Reserve University, Cleveland, OH, USA
⁵ Inspirata Inc., Tampa, FL, USA
⁶ Department of Pathology, University of Michigan, Ann Arbor, MI, USA
⁷ Laboratory of Pathology, National Cancer Institute, Bethesda; Medimmune, LLC, Gaithersburg, MD, USA
⁸ Google Inc., Mountain View, CA, USA
⁹ Laboratory of Pathology, National Cancer Institute, Bethesda, MD; Division of Translational Pathology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA
¹⁰ Laboratory of Pathology, National Cancer Institute, Bethesda, MD; Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA
¹¹ Laboratory of Pathology, National Cancer Institute, Bethesda, MD, USA
¹² Laboratory of Pathology, National Cancer Institute, Bethesda, MD; Avoneaux Medical Institute, LLC, Baltimore, MD, USA
¹³ Laboratory of Pathology, National Cancer Institute, Bethesda; Alvin and Lois Lapidus Cancer Institute, Sinai Hospital of Baltimore, LifeBridge Health, Baltimore, MD, USA

Correspondence Address:
Dr. Michael A Tangrea
Alvin and Lois Lapidus Cancer Institute, Sinai Hospital of Baltimore, Lifebridge Health, 2401 W. Belvedere Ave, Schapiro Building, Room 203 Baltimore, MD 21215
USA

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/jpi.jpi_60_18