Contact us
|
Home
|
Login
| Users Online: 638
Feedback
Subscribe
Advertise
Search
Advanced Search
Month wise articles
Figures next to the month indicate the number of articles in that month
2022
January
[
3
]
2021
November
[
2
]
September
[
3
]
August
[
1
]
June
[
2
]
January
[
1
]
2020
November
[
3
]
August
[
1
]
July
[
1
]
May
[
1
]
February
[
1
]
2019
December
[
2
]
September
[
1
]
August
[
2
]
July
[
2
]
June
[
1
]
May
[
1
]
April
[
1
]
March
[
1
]
February
[
2
]
2018
December
[
4
]
November
[
1
]
August
[
1
]
July
[
1
]
May
[
1
]
2017
October
[
1
]
September
[
3
]
June
[
1
]
May
[
1
]
March
[
1
]
February
[
1
]
2016
April
[
1
]
March
[
1
]
January
[
2
]
2015
October
[
3
]
September
[
3
]
June
[
4
]
March
[
2
]
January
[
1
]
2014
October
[
2
]
September
[
2
]
August
[
2
]
July
[
1
]
June
[
1
]
May
[
1
]
March
[
1
]
January
[
2
]
2013
December
[
2
]
November
[
1
]
July
[
1
]
June
[
1
]
March
[
2
]
2012
December
[
1
]
September
[
3
]
August
[
1
]
July
[
1
]
April
[
3
]
March
[
1
]
February
[
1
]
2011
August
[
2
]
July
[
2
]
June
[
1
]
May
[
1
]
March
[
2
]
January
[
1
]
2010
October
[
3
]
» Articles published in the past year
To view other articles click corresponding year from the navigation links on the left side.
All
|
Abstracts
|
Book Review
|
Commentary
|
Editorial
|
Letters to Editor
|
Original Article
|
Original Articles
|
PV16 Abstracts
|
Research Article
|
Review Articles
|
Symposium
|
Technical Note
Export selected to
Endnote
Reference Manager
Procite
Medlars Format
RefWorks Format
BibTex Format
Show all abstracts
Show selected abstracts
Export selected to
Add to my list
Research Article:
Usability evaluation of laboratory information systems
Althea Mathews, David Marc
J Pathol Inform
2017, 8:40 (3 October 2017)
DOI
:10.4103/jpi.jpi_24_17
PMID
:29114434
Background:
Numerous studies have revealed widespread clinician frustration with the usability of electronic health records (EHRs) that is counterproductive to adoption of EHR systems to meet the aims of health-care reform. With poor system usability comes increased risk of negative unintended consequences. Usability issues could lead to user error and workarounds that have the potential to compromise patient safety and negatively impact the quality of care.
[1]
While there is ample research on EHR usability, there is little information on the usability of laboratory information systems (LISs). Yet, LISs facilitate the timely provision of a great deal of the information needed by physicians to make patient care decisions.
[2]
Medical and technical advances in genomics that require processing of an increased volume of complex laboratory data further underscore the importance of developing user-friendly LISs. This study aims to add to the body of knowledge on LIS usability.
Methods:
A survey was distributed among LIS users at hospitals across the United States. The survey consisted of the ten-item System Usability Scale (SUS). In addition, participants were asked to rate the ease of performing 24 common tasks with a LIS. Finally, respondents provided comments on what they liked and disliked about using the LIS to provide diagnostic insight into LIS perceived usability.
Results:
The overall mean SUS score of 59.7 for the LIS evaluated is significantly lower than the benchmark of 68 (
P
< 0.001). All LISs evaluated received mean SUS scores below 68 except for Orchard Harvest (78.7). While the years of experience using the LIS was found to be a statistically significant influence on mean SUS scores, the combined effect of years of experience and LIS used did not account for the statistically significant difference in the mean SUS score between Orchard Harvest and each of the other LISs evaluated.
Conclusions:
The results of this study indicate that overall usability of LISs is poor. Usability lags that of systems evaluated across 446 usability surveys.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (1) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Research Article:
Robotic telecytology for remote cytologic evaluation without an on-site cytotechnologist or cytopathologist: an active quality assessment and experience of over 400 cases
Sahussapont Joseph Sirintrapun, Dorota Rudomina, Allix Mazzella, Rusmir Feratovic, William Alago, Robert Siegelbaum, Oscar Lin
J Pathol Inform
2017, 8:35 (7 September 2017)
DOI
:10.4103/jpi.jpi_25_17
PMID
:28966835
Background:
The first satellite center to offer interventional radiology procedures at Memorial Sloan Kettering Cancer Center opened in October 2014. Two of the procedures offered, fine needle aspirations and core biopsies, required a rapid on-site cytologic evaluation of smears and biopsy touch imprints for cellular content and adequacy. The volume and frequency of such evaluations did not justify hiring on-site cytotechnologists, and therefore, a dynamic robotic telecytology (TC) solution was created. In this article, we provide data on our experience with this active implementation. Sakura VisionTek was selected as our robotic TC solution.
Methods:
A retrospective analysis of all TC evaluations from this satellite site was performed. Information was collected on demographics, lesion location, imaging modality; a comparison of TC-assisted adequacy with final adequacy was also conducted.
Results:
An analysis of 439 cases was performed over a period of 23 months with perfect correlation in 92.7% (407/439) of the cases. An adequacy upgrade (inadequate specimen becomes adequate) in 6.6% (29/439) of the cases. An adequacy downgrade (adequate specimen becomes inadequate), is near zero at 0.7% (3/439) of the cases.
Conclusions:
Dynamic robotic TC is effective for immediate evaluations performed without on-site cytotechnology staff. The overall intent of this article is to present data and concordance rates as outcome metrics. Thus far, such outcome metrics have exceeded our expectations. Our TC implementation shows high, perfect concordance. Adequacy upgrades are minor but more relevant and impressive is a near zero adequacy downgrade. Our full implementation has been so successful that plans are in place for configurations at future satellite sites.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (5) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Research Article:
Successful secure high-definition streaming telecytology for remote cytologic evaluation
Sahussapont Joseph Sirintrapun, Dorota Rudomina, Allix Mazzella, Rusmir Feratovic, Oscar Lin
J Pathol Inform
2017, 8:33 (7 September 2017)
DOI
:10.4103/jpi.jpi_18_17
PMID
:28966833
Background:
The use of minimally invasive procedures to obtain material for diagnostic purposes has become more prevalent in recent years. As such, there is increased demand for immediate cytologic adequacy assessment of minimally invasive procedures. The array of different locations in which rapid on-site evaluation (ROSE) is expected requires an ever-increasing number of cytology personnel to provide support for adequacy assessment. In our study, we describe the implementation process of a telecytology (TC) system in a high case volume setting and evaluate the performance of this activity.
Methods:
We performed retrospectively an analysis of all consecutive remote TC ROSE evaluations obtained for 15 months. The specimens were evaluated using a TC system. The ROSE adequacy assessment obtained at the time of the procedure was compared to the final cytopathologist-rendered adequacy assessment when all the material was available for review, including the alcohol-fixed preparations.
Results:
A total of 8106 distinct cases were analyzed. TC-assisted preliminary adequacy assessment was highly concordant with the final cytopathologist-rendered adequacy assessment. Perfect concordance or accuracy was at 93.1% (7547/8106). The adequacy upgrade rate (inadequate specimen became adequate) was 6.8% (551/8106), and the initial adequacy downgrade (adequate specimen became inadequate) was <0.1% (8/8106).
Conclusions:
The TC outcome demonstrates high concordance between the initial adequacy assessment and final cytopathologist-rendered adequacy assessment. Adequacy upgrades were minor but, more importantly, our results demonstrate a minimal adequacy downgrade. The process implemented effectively eliminated the need for an attending pathologist to be physically present onsite during a biopsy procedure.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (6) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Research Article:
A design study investigating augmented reality and photograph annotation in a digitalized grossing workstation
Joyce A Chow, Martin E Törnros, Marie Waltersson, Helen Richard, Madeleine Kusoffsky, Claes F Lundström, Arianit Kurti
J Pathol Inform
2017, 8:31 (7 September 2017)
DOI
:10.4103/jpi.jpi_13_17
PMID
:28966831
Context:
Within digital pathology, digitalization of the grossing procedure has been relatively underexplored in comparison to digitalization of pathology slides.
Aims:
Our investigation focuses on the interaction design of an augmented reality gross pathology workstation and refining the interface so that information and visualizations are easily recorded and displayed in a thoughtful view.
Settings and Design:
The work in this project occurred in two phases: the first phase focused on implementation of an augmented reality grossing workstation prototype while the second phase focused on the implementation of an incremental prototype in parallel with a deeper design study.
Subjects and Methods:
Our research institute focused on an experimental and “designerly” approach to create a digital gross pathology prototype as opposed to focusing on developing a system for immediate clinical deployment.
Statistical Analysis Used:
Evaluation has not been limited to user tests and interviews, but rather key insights were uncovered through design methods such as “
rapid ethnography
” and “
conversation with materials
”.
Results:
We developed an augmented reality enhanced digital grossing station prototype to assist pathology technicians in capturing data during examination. The prototype uses a magnetically tracked scalpel to annotate planned cuts and dimensions onto photographs taken of the work surface. This article focuses on the use of qualitative design methods to evaluate and refine the prototype. Our aims were to build on the strengths of the prototype's technology, improve the ergonomics of the digital/physical workstation by considering numerous alternative design directions, and to consider the effects of digitalization on personnel and the pathology diagnostics information flow from a wider perspective. A proposed interface design allows the pathology technician to place images in relation to its orientation, annotate directly on the image, and create linked information.
Conclusions:
The augmented reality magnetically tracked scalpel reduces tool switching though limitations in today's augmented reality technology fall short of creating an ideal immersive workflow by requiring the use of a monitor. While this technology catches up, we recommend focusing efforts on enabling the easy creation of layered, complex reports, linking, and viewing information across systems. Reflecting upon our results, we argue for digitalization to focus not only on how to record increasing amounts of data but also how these data can be accessed in a more thoughtful way that draws upon the expertise and creativity of pathology professionals using the systems.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (1) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Research Article:
A reduced set of features for chronic kidney disease prediction
Rajesh Misir, Malay Mitra, Ranjit Kumar Samanta
J Pathol Inform
2017, 8:24 (19 June 2017)
DOI
:10.4103/jpi.jpi_88_16
PMID
:28706750
Chronic kidney disease (CKD) is one of the life-threatening diseases. Early detection and proper management are solicited for augmenting survivability. As per the UCI data set, there are 24 attributes for predicting CKD or non-CKD. At least there are 16 attributes need pathological investigations involving more resources, money, time, and uncertainties. The objective of this work is to explore whether we can predict CKD or non-CKD with reasonable accuracy using less number of features. An intelligent system development approach has been used in this study. We attempted one important feature selection technique to discover reduced features that explain the data set much better. Two intelligent binary classification techniques have been adopted for the validity of the reduced feature set. Performances were evaluated in terms of four important classification evaluation parameters. As suggested from our results, we may more concentrate on those reduced features for identifying CKD and thereby reduces uncertainty, saves time, and reduces costs.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (3) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Research Article:
Training nuclei detection algorithms with simple annotations
Henning Kost, André Homeyer, Jesper Molin, Claes Lundström, Horst Karl Hahn
J Pathol Inform
2017, 8:21 (15 May 2017)
DOI
:10.4103/jpi.jpi_3_17
PMID
:28584683
Background:
Generating good training datasets is essential for machine learning-based nuclei detection methods. However, creating exhaustive nuclei contour annotations, to derive optimal training data from, is often infeasible.
Methods:
We compared different approaches for training nuclei detection methods solely based on nucleus center markers. Such markers contain less accurate information, especially with regard to nuclear boundaries, but can be produced much easier and in greater quantities. The approaches use different automated sample extraction methods to derive image positions and class labels from nucleus center markers. In addition, the approaches use different automated sample selection methods to improve the detection quality of the classification algorithm and reduce the run time of the training process. We evaluated the approaches based on a previously published generic nuclei detection algorithm and a set of Ki-67-stained breast cancer images.
Results:
A Voronoi tessellation-based sample extraction method produced the best performing training sets. However, subsampling of the extracted training samples was crucial. Even simple class balancing improved the detection quality considerably. The incorporation of active learning led to a further increase in detection quality.
Conclusions:
With appropriate sample extraction and selection methods, nuclei detection algorithms trained on the basis of simple center marker annotations can produce comparable quality to algorithms trained on conventionally created training sets.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (2) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Research Article:
A randomized study comparing digital imaging to traditional glass slide microscopy for breast biopsy and cancer diagnosis
Joann G Elmore, Gary M Longton, Margaret S Pepe, Patricia A Carney, Heidi D Nelson, Kimberly H Allison, Berta M Geller, Tracy Onega, Anna N. A Tosteson, Ezgi Mercan, Linda G Shapiro, Tad T Brunyé, Thomas R Morgan, Donald L Weaver
J Pathol Inform
2017, 8:12 (10 March 2017)
DOI
:10.4103/2153-3539.201920
PMID
:28382226
Background:
Digital whole slide imaging may be useful for obtaining second opinions and is used in many countries. However, the U.S. Food and Drug Administration requires verification studies.
Methods:
Pathologists were randomized to interpret one of four sets of breast biopsy cases during two phases, separated by ≥9 months, using glass slides or digital format (sixty cases per set, one slide per case,
n
= 240 cases). Accuracy was assessed by comparing interpretations to a consensus reference standard. Intraobserver reproducibility was assessed by comparing the agreement of interpretations on the same cases between two phases. Estimated probabilities of confirmation by a reference panel (i.e., predictive values) were obtained by incorporating data on the population prevalence of diagnoses.
Results:
Sixty-five percent of responding pathologists were eligible, and 252 consented to randomization; 208 completed Phase I (115 glass, 93 digital); and 172 completed Phase II (86 glass, 86 digital). Accuracy was slightly higher using glass compared to digital format and varied by category: invasive carcinoma, 96% versus 93% (
P
= 0.04); ductal carcinoma
in situ
(DCIS), 84% versus 79% (
P
< 0.01); atypia, 48% versus 43% (
P
= 0.08); and benign without atypia, 87% versus 82% (
P
< 0.01). There was a small decrease in intraobserver agreement when the format changed compared to when glass slides were used in both phases (
P
= 0.08). Predictive values for confirmation by a reference panel using glass versus digital were: invasive carcinoma, 98% and 97% (not significant [NS]); DCIS, 70% and 57% (
P
= 0.007); atypia, 38% and 28% (
P
= 0.002); and benign without atypia, 97% and 96% (NS).
Conclusions:
In this large randomized study, digital format interpretations were similar to glass slide interpretations of benign and invasive cancer cases. However, cases in the middle of the spectrum, where more inherent variability exists, may be more problematic in digital format. Future studies evaluating the effect these findings exert on clinical practice and patient outcomes are required.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (10) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Research Article:
Pathological diagnosis of gastric cancers with a novel computerized analysis system
Kosuke Oikawa, Akira Saito, Tomoharu Kiyuna, Hans Peter Graf, Eric Cosatto, Masahiko Kuroda
J Pathol Inform
2017, 8:5 (28 February 2017)
DOI
:10.4103/2153-3539.201114
PMID
:28400994
Background:
Recent studies of molecular biology have provided great advances for diagnostic molecular pathology. Automated diagnostic systems with computerized scanning for sampled cells in fluids or smears are now widely utilized. Automated analysis of tissue sections is, however, very difficult because they exhibit a complex mixture of overlapping malignant tumor cells, benign host-derived cells, and extracellular materials. Thus, traditional histological diagnosis is still the most powerful method for diagnosis of diseases.
Methods:
We have developed a novel computer-assisted pathology system for rapid, automated histological analysis of hematoxylin and eosin (H and E)-stained sections. It is a multistage recognition system patterned after methods that human pathologists use for diagnosis but harnessing machine learning and image analysis. The system first analyzes an entire H and E-stained section (tissue) at low resolution to search suspicious areas for cancer and then the selected areas are analyzed at high resolution to confirm the initial suspicion.
Results:
After training the pathology system with gastric tissues samples, we examined its performance using other 1905 gastric tissues. The system's accuracy in detecting malignancies was shown to be almost equal to that of conventional diagnosis by expert pathologists.
Conclusions:
Our novel computerized analysis system provides a support for histological diagnosis, which is useful for screening and quality control. We consider that it could be extended to be applicable to many other carcinomas after learning normal and malignant forms of various tissues. Furthermore, we expect it to contribute to the development of more objective grading systems, immunohistochemical staining systems, and fluorescent-stained image analysis systems.
[ABSTRACT]
[HTML Full text]
[PDF]
[Mobile Full text]
[EPub]
[Citations (5) ]
[PubMed]
[Sword Plugin for Repository]
Beta
Sitemap
|
What's New
Feedback
|
Copyright and Disclaimer
|
Privacy Notice
© Journal of Pathology Informatics | Published by Wolters Kluwer -
Medknow
Online since 10
th
March, 2010