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Month wise articles
Figures next to the month indicate the number of articles in that month
2022
March
[
1
]
January
[
10
]
2021
December
[
7
]
November
[
9
]
September
[
8
]
August
[
2
]
July
[
1
]
June
[
4
]
May
[
3
]
April
[
4
]
March
[
7
]
February
[
3
]
January
[
6
]
2020
December
[
2
]
November
[
5
]
October
[
3
]
September
[
2
]
August
[
8
]
July
[
4
]
June
[
2
]
May
[
1
]
April
[
3
]
March
[
3
]
February
[
6
]
January
[
1
]
2019
December
[
6
]
November
[
4
]
September
[
4
]
August
[
3
]
July
[
6
]
June
[
1
]
May
[
2
]
April
[
6
]
March
[
3
]
February
[
4
]
January
[
2
]
2018
December
[
10
]
November
[
4
]
October
[
3
]
September
[
4
]
August
[
1
]
July
[
3
]
June
[
5
]
May
[
4
]
April
[
10
]
March
[
2
]
February
[
4
]
2017
December
[
5
]
November
[
4
]
October
[
3
]
September
[
9
]
July
[
5
]
June
[
2
]
May
[
4
]
April
[
6
]
March
[
6
]
February
[
7
]
2016
December
[
7
]
November
[
5
]
October
[
3
]
September
[
7
]
August
[
1
]
July
[
7
]
May
[
8
]
April
[
7
]
March
[
4
]
February
[
2
]
January
[
5
]
2015
November
[
4
]
October
[
5
]
September
[
5
]
August
[
4
]
July
[
3
]
June
[
19
]
May
[
5
]
April
[
1
]
March
[
5
]
February
[
9
]
January
[
3
]
2014
November
[
2
]
October
[
5
]
September
[
4
]
August
[
6
]
July
[
8
]
June
[
1
]
May
[
3
]
March
[
8
]
February
[
3
]
January
[
4
]
2013
December
[
5
]
November
[
2
]
October
[
4
]
September
[
4
]
August
[
3
]
July
[
3
]
June
[
5
]
May
[
7
]
March
[
18
]
February
[
1
]
January
[
1
]
2012
December
[
6
]
November
[
1
]
October
[
4
]
September
[
4
]
August
[
7
]
July
[
2
]
June
[
1
]
May
[
2
]
April
[
7
]
March
[
6
]
February
[
7
]
January
[
13
]
2011
December
[
3
]
November
[
1
]
October
[
7
]
August
[
9
]
July
[
3
]
June
[
7
]
May
[
3
]
March
[
6
]
February
[
8
]
January
[
6
]
2010
December
[
4
]
November
[
1
]
October
[
6
]
September
[
1
]
August
[
6
]
July
[
6
]
May
[
5
]
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Review Article:
Next generation sequencing in clinical medicine: Challenges and lessons for pathology and biomedical informatics
Rama R Gullapalli, Ketaki V Desai, Lucas Santana-Santos, Jeffrey A Kant, Michael J Becich
J Pathol Inform
2012, 3:40 (31 October 2012)
DOI
:10.4103/2153-3539.103013
PMID
:23248761
The Human Genome Project (HGP) provided the initial draft of mankind's DNA sequence in 2001. The HGP was produced by 23 collaborating laboratories using Sanger sequencing of mapped regions as well as shotgun sequencing techniques in a process that occupied 13 years at a cost of ~$3 billion. Today, Next Generation Sequencing (NGS) techniques represent the next phase in the evolution of DNA sequencing technology at dramatically reduced cost compared to traditional Sanger sequencing. A single laboratory today can sequence the entire human genome in a few days for a few thousand dollars in reagents and staff time. Routine whole exome or even whole genome sequencing of clinical patients is well within the realm of affordability for many academic institutions across the country. This paper reviews current sequencing technology methods and upcoming advancements in sequencing technology as well as challenges associated with data generation, data manipulation and data storage. Implementation of routine NGS data in cancer genomics is discussed along with potential pitfalls in the interpretation of the NGS data. The overarching importance of bioinformatics in the clinical implementation of NGS is emphasized.
[7]
We also review the issue of physician education which also is an important consideration for the successful implementation of NGS in the clinical workplace. NGS technologies represent a golden opportunity for the next generation of pathologists to be at the leading edge of the personalized medicine approaches coming our way. Often under-emphasized issues of data access and control as well as potential ethical implications of whole genome NGS sequencing are also discussed. Despite some challenges, it's hard not to be optimistic about the future of personalized genome sequencing and its potential impact on patient care and the advancement of knowledge of human biology and disease in the near future.
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Commentary:
Evaluation of whole slide imaging for routine surgical pathology: Looking through a broader scope
Walter H Henricks
J Pathol Inform
2012, 3:39 (31 October 2012)
DOI
:10.4103/2153-3539.103009
PMID
:23248760
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Book Review:
Review of "Pathology informatics: Theory and practice" by L Pantanowitz, JM Tuthill, and UGJ Balis (Editors)
Myra L Wilkerson
J Pathol Inform
2012, 3:38 (31 October 2012)
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Abstract:
Abstracts: Pathology Informatics 2012
J Pathol Inform
2012, 3:37 (9 October 2012)
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© Journal of Pathology Informatics | Published by Wolters Kluwer -
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Online since 10
th
March, 2010