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Month wise articles
Figures next to the month indicate the number of articles in that month
2022
March
[
1
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January
[
10
]
2021
December
[
7
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November
[
9
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September
[
8
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August
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2
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July
[
1
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June
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4
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May
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3
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April
[
4
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March
[
7
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February
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3
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January
[
6
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2020
December
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2
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November
[
5
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October
[
3
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September
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2
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August
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8
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July
[
4
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June
[
2
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May
[
1
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April
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3
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March
[
3
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February
[
6
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January
[
1
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2019
December
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6
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November
[
4
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September
[
4
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August
[
3
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July
[
6
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June
[
1
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May
[
2
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April
[
6
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March
[
3
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February
[
4
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January
[
2
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2018
December
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10
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November
[
4
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October
[
3
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September
[
4
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August
[
1
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July
[
3
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June
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5
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May
[
4
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April
[
10
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March
[
2
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February
[
4
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2017
December
[
5
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November
[
4
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October
[
3
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September
[
9
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July
[
5
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June
[
2
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May
[
4
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April
[
6
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March
[
6
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February
[
7
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2016
December
[
7
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November
[
5
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October
[
3
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September
[
7
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August
[
1
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July
[
7
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May
[
8
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April
[
7
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March
[
4
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February
[
2
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January
[
5
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2015
November
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4
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October
[
5
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September
[
5
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August
[
4
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July
[
3
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June
[
19
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May
[
5
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April
[
1
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March
[
5
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February
[
9
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January
[
3
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2014
November
[
2
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October
[
5
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September
[
4
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August
[
6
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July
[
8
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June
[
1
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May
[
3
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March
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8
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February
[
3
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January
[
4
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2013
December
[
5
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November
[
2
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October
[
4
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September
[
4
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August
[
3
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July
[
3
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June
[
5
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May
[
7
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March
[
18
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February
[
1
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January
[
1
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2012
December
[
6
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November
[
1
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October
[
4
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September
[
4
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August
[
7
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July
[
2
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June
[
1
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May
[
2
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April
[
7
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March
[
6
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February
[
7
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January
[
13
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2011
December
[
3
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November
[
1
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October
[
7
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August
[
9
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July
[
3
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June
[
7
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May
[
3
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March
[
6
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February
[
8
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January
[
6
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2010
December
[
4
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November
[
1
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October
[
6
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September
[
1
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August
[
6
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July
[
6
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May
[
5
]
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Technical Note:
Remote reporting during a pandemic using digital pathology solution: Experience from a tertiary care cancer center
Veena Ramaswamy, BN Tejaswini, Sowmya B Uthaiah
J Pathol Inform
2021, 12:20 (8 April 2021)
DOI
:10.4103/jpi.jpi_109_20
Background:
Remote reporting in anatomic pathology is an important advantage of digital pathology that has not been much explored. The COVID-19 pandemic has provided an opportunity to explore this important application of digital pathology system in a tertiary care cancer center to ensure patient care and staff safety. Regulatory guidelines have been described for remote reporting following the pandemic. Herein, we describe our experience of validation of digital pathology workflow for remote reporting to encourage pathologists to utilize this facility which opens door for multiple, multidisciplinary collaborations.
Objective:
To demonstrate the validation and the operational feasibility of remote reporting using a digital pathology system.
Materials and Methods:
Our retrospective validation included whole-slide images (WSIs) of 60 cases of histopathology and 20 cases each of frozen sections and a digital image-based breast algorithm after a washout period of 3 months. Three pathologists with different models of consumer-grade laptops reviewed the cases remotely to assess the diagnostic concordance and operational feasibility of the modified workflow. The slides were digitized on a USFDA-approved Philips UFS 300 scanner at ×40 resolution (0.25 μm/pixel) and viewed on the Image Management System through a web browser. All the essential parameters were reported for each case. After successful validation, 886 cases were reported remotely from March 29, 2020, to June 30, 2020, prospectively. Light microscopy formed the gold standard reference in remote reporting.
Results:
100% major diagnostic concordance was observed in the validation of remote reporting in the retrospective and prospective studies using consumer-grade laptops. The deferral rate was 0.34%. 97.6% of histopathology and 100% of frozen sections were signed out within the turnaround time. Network speed and a lack of virtual private network did not significantly affect the study.
Conclusion:
This study of validation and reporting of complete pathology cases remotely, including their operational feasibility during a public health emergency, proves that remote sign-out using a digital pathology system is not inferior to WSIs on medical-grade monitors and light microscopy. Such studies on remote reporting open the door for the use of digital pathology for interinstitutional consultation and collaboration: Its main intended use.
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Technical Note:
Use of middleware data to dissect and optimize hematology autoverification
Rachel D Starks, Anna E Merrill, Scott R Davis, Dena R Voss, Pamela J Goldsmith, Bonnie S Brown, Jeff Kulhavy, Matthew D Krasowski
J Pathol Inform
2021, 12:19 (7 April 2021)
DOI
:10.4103/jpi.jpi_89_20
Background:
Hematology analysis comprises some of the highest volume tests run in clinical laboratories. Autoverification of hematology results using computer-based rules reduces turnaround time for many specimens, while strategically targeting specimen review by technologist or pathologist.
Methods:
Autoverification rules had been developed over a decade at an 800-bed tertiary/quarternary care academic medical central laboratory serving both adult and pediatric populations. In the process of migrating to newer hematology instruments, we analyzed the rates of the autoverification rules/flags most commonly associated with triggering manual review. We were particularly interested in rules that on their own often led to manual review in the absence of other flags. Prior to the study, autoverification rates were 87.8% (out of 16,073 orders) for complete blood count (CBC) if ordered as a panel and 85.8% (out of 1,940 orders) for CBC components ordered individually (not as the panel).
Results:
Detailed analysis of rules/flags that frequently triggered indicated that the immature granulocyte (IG) flag (an instrument parameter) and rules that reflexed platelet by impedance method (PLT-I) to platelet by fluorescent method (PLT-F) represented the two biggest opportunities to increase autoverification. The IG flag threshold had previously been validated at 2%, a setting that resulted in this flag alone preventing autoverification in 6.0% of all samples. The IG flag threshold was raised to 5% after detailed chart review; this was also the instrument vendor's default recommendation for the newer hematology analyzers. Analysis also supported switching to PLT-F for all platelet analysis. Autoverification rates increased to 93.5% (out of 91,692 orders) for CBC as a panel and 89.8% (out of 11,982 orders) for individual components after changes in rules and laboratory practice.
Conclusions:
Detailed analysis of autoverification of hematology testing at an academic medical center clinical laboratory that had been using a set of autoverification rules for over a decade revealed opportunities to optimize the parameters. The data analysis was challenging and time-consuming, highlighting opportunities for improvement in software tools that allow for more rapid and routine evaluation of autoverification parameters.
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Technical Note:
Image Analysis Using Machine Learning for Automated Detection of Hemoglobin H Inclusions in Blood Smears – A Method for Morphologic Detection of Rare Cells
Shir Ying Lee, Crystal M E Chen, Elaine Y P Lim, Liang Shen, Aneesh Sathe, Aahan Singh, Jan Sauer, Kaveh Taghipour, Christina Y C Yip
J Pathol Inform
2021, 12:18 (7 April 2021)
DOI
:10.4103/jpi.jpi_110_20
Background: Morphologic rare cell detection is a laborious, operator-dependent process which has the potential to be improved by the use of image analysis using artificial intelligence. Detection of rare hemoglobin H (HbH) inclusions in red cells in the peripheral blood is a common screening method for alpha-thalassemia. This study aims to develop a convolutional neural network-based algorithm for the detection of HbH inclusions.
Methods:
Digital images of HbH-positive and HbH-negative blood smears were used to train and test the software. The software performance was tested on images obtained at various magnifications and on different scanning platforms. Another model was developed for total red cell counting and was used to confirm HbH cell frequency in alpha-thalassemia trait. The threshold minimum red cells to image for analysis was determined by Poisson modeling and validated on image sets.
Results:
The sensitivity and specificity of the software for HbH+ cells on images obtained at ×100, ×60, and ×40 objectives were close to 91% and 99%, respectively. When an AI-aided diagnostic model was tested on a pilot of 40 whole slide images (WSIs), good inter-rater reliability and high sensitivity and specificity of slide-level classification were obtained. Using the lowest frequency of HbH+ cells (1 in 100,000) observed in our study, we estimated that a minimum of 2.4 × 106 red cells would need to be analyzed to reduce misclassification at the slide level. The minimum required smear size was validated on 78 image sets which confirmed its validity.
Conclusions:
WSI image analysis can be utilized effectively for morphologic rare cell detection. The software can be further developed on WISs and evaluated in future clinical validation studies comparing AI-aided diagnosis with the routine diagnostic method.
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Original Article:
Dissecting the business case for adoption and implementation of digital pathology: A white paper from the digital pathology association
Giovanni Lujan, Jennifer C Quigley, Douglas Hartman, Anil Parwani, Brian Roehmholdt, Bryan Van Meter, Orly Ardon, Matthew G Hanna, Dan Kelly, Chelsea Sowards, Michael Montalto, Marilyn Bui, Mark D Zarella, Victoria LaRosa, Gerard Slootweg, Juan Antonio Retamero, Mark C Lloyd, James Madory, Doug Bowman
J Pathol Inform
2021, 12:17 (7 April 2021)
DOI
:10.4103/jpi.jpi_67_20
We believe the switch to a digital pathology (DP) workflow is imminent and it is essential to understand the economic implications of conversion. Many aspects of the adoption of DP will be disruptive and have a direct financial impact, both in short term costs, such as investment in equipment and personnel, and long term revenue potential, such as improved productivity and novel tests. The focus of this whitepaper is to educate pathologists, laboratorians and other stakeholders about the business and monetary considerations of converting to a digital pathology workflow. The components of a DP business plan will be thoroughly summarized, and guidance will be provided on how to build a case for adoption and implementation as well as a roadmap for transitioning from an analog to a digital pathology workflow in various laboratory settings. It is important to clarify that this publication is not intended to list prices although some financials will be mentioned as examples. The authors encourage readers who are evaluating conversion to a DP workflow to use this paper as a foundational guide for conducting a thorough and complete assessment while incorporating in current market pricing. Contributors to this paper analyzed peer-reviewed literature and data collected from various institutions, some of which are mentioned. Digital pathology will change the way we practice through facilitating patient access to expert pathology services and enabling image analysis tools and assays to aid in diagnosis, prognosis, risk stratification and therapeutic selection. Together, they will result in the delivery of valuable information from which to make better decisions and improve the health of patients.
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March, 2010