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Original Article:
Colorectal cancer detection based on deep learning
Lin Xu, Blair Walker, Peir-In Liang, Yi Tong, Cheng Xu, Yu Chun Su, Aly Karsan
J Pathol Inform
2020, 11:28 (21 August 2020)
DOI
:10.4103/jpi.jpi_68_19
Introduction:
The initial point in the diagnostic workup of solid tumors remains manual, with the assessment of hematoxylin and eosin (H&E)-stained tissue sections by microscopy. This is a labor-intensive step that requires attention to detail. In addition, diagnoses are influenced by an individual pathologist's knowledge and experience and may not always be reproducible between pathologists.
Methods:
We introduce a deep learning-based method in colorectal cancer detection and segmentation from digitized H&E-stained histology slides.
Results:
In this study, we demonstrate that this neural network approach produces median accuracy of 99.9% for normal slides and 94.8% for cancer slides compared to pathologist-based diagnosis on H&E-stained slides digitized from clinical samples.
Conclusion:
Given that our approach has very high accuracy on normal slides, use of neural network algorithms may provide a screening approach to save pathologist time in identifying tumor regions. We suggest that this new method may be a powerful assistant for colorectal cancer diagnostics.
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Original Article:
LibMI: An open source library for efficient histopathological image processing
Yuxin Dong, Pargorn Puttapirat, Jingyi Deng, Xiangrong Zhang, Chen Li
J Pathol Inform
2020, 11:26 (21 August 2020)
DOI
:10.4103/jpi.jpi_11_20
Background:
Whole-slide images (WSIs) as a kind of image data are rapidly growing in the digital pathology domain. With unusual high resolution, these images make them hard to be supported by conventional tools or file formats. Thus, it obstructs data sharing and automated analysis. Here, we propose a library, LibMI, along with its open and standardized image file format. They can be used together to efficiently read, write, modify, and annotate large images.
Materials and Methods:
LibMI utilizes the concept of pyramid image structure and lazy propagation from a segment tree algorithm to support reading and modifying and to guarantee that both operations have linear time complexity. Further, a cache mechanism was introduced to speed up the program.
Results:
LibMI is an open and efficient library for histopathological image processing. To demonstrate its functions, we applied it to several tasks including image thresholding, microscopic color correction, and storing pixel-wise information on WSIs. The result shows that libMI is particularly suitable for modifying large images. Furthermore, compared with congeneric libraries and file formats, libMI and modifiable multiscale image (MMSI) run 18.237 times faster on read-only tasks.
Conclusions:
The combination of libMI library and MMSI file format enables developers to efficiently read and modify WSIs, thus can assist in pixel-wise image processing on extremely large images to promote building image processing pipeline. The library together with the data schema is freely available on GitLab:
https://gitlab.com/BioAI/libMI
.
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Original Article:
A regulatory science initiative to harmonize and standardize digital pathology and machine learning processes to speed up clinical innovation to patients
Hetal Desai Marble, Richard Huang, Sarah Nixon Dudgeon, Amanda Lowe, Markus D Herrmann, Scott Blakely, Matthew O Leavitt, Mike Isaacs, Matthew G Hanna, Ashish Sharma, Jithesh Veetil, Pamela Goldberg, Joachim H Schmid, Laura Lasiter, Brandon D Gallas, Esther Abels, Jochen K Lennerz
J Pathol Inform
2020, 11:22 (6 August 2020)
DOI
:10.4103/jpi.jpi_27_20
Unlocking the full potential of pathology data by gaining computational access to histological pixel data and metadata (digital pathology) is one of the key promises of computational pathology. Despite scientific progress and several regulatory approvals for primary diagnosis using whole-slide imaging, true clinical adoption at scale is slower than anticipated. In the U.S., advances in digital pathology are often siloed pursuits by individual stakeholders, and to our knowledge, there has not been a systematic approach to advance the field through a regulatory science initiative. The Alliance for Digital Pathology ( the
Alliance)
is a recently established, volunteer, collaborative, regulatory science initiative to standardize digital pathology processes to speed up innovation to patients. The purpose is: (1) to account for the patient perspective by including patient advocacy; (2) to investigate and develop methods and tools for the evaluation of effectiveness, safety, and quality to specify risks and benefits in the precompetitive phase; (3) to help strategize the sequence of clinically meaningful deliverables; (4) to encourage and streamline the development of ground-truth data sets for machine learning model development and validation; and (5) to clarify regulatory pathways by investigating relevant regulatory science questions. The
Alliance
accepts participation from all stakeholders, and we solicit clinically relevant proposals that will benefit the field at large. The initiative will dissolve once a clinical, interoperable, modularized, integrated solution (from tissue acquisition to diagnostic algorithm) has been implemented. In times of rapidly evolving discoveries, scientific input from subject-matter experts is one essential element to inform regulatory guidance and decision-making. The
Alliance
aims to establish and promote synergistic regulatory science efforts that will leverage diverse inputs to move digital pathology forward and ultimately improve patient care.
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Original Article:
Improving critical value notification through secure text messaging
Terrance James Lynn, Jordan Erik Olson
J Pathol Inform
2020, 11:21 (6 August 2020)
DOI
:10.4103/jpi.jpi_19_20
Background:
To improve communication between clinical providers and the laboratory, we recently implemented secure text messaging for our critical value notifications. This was done to communicate laboratory critical values (CV) to providers faster so changes to patient care could be done faster. Our previous method of communicating CV to providers was paging and relied on a call back to receive the critical value.
Methods:
We implemented delivery of CV through a secure texting application in which the CV was directly communicated to the provider on their smart phone device.
Results:
The mean pre-implementation turnaround time (TAT) was 11.3 minutes (median: 7 minutes, range: 0 - 210 minutes). The mean post- secure text messaging implementation TAT was 3.03 minutes (median: 0.89 minutes, range: < 1 - 95 minutes).When comparing pre- and post-implementation, there was a significant reduction in the TAT from using secure text messaging (p < 0.001). Of the 234 surveys sent out, 81 providers responded (35%). Of these responses, 85% reported that critical value notification by secure text messaging has increased their efficiency and 95% reported that critical value notification is more effective than a pager-phone-call based system. 83% of providers reported that they were able to provide better, faster care to their patients.
Conclusions:
Using secure text messaging (STM) to deliver critical values significantly reduces the CV TAT. Furthermore, providers noted they preferred to receive CV notifications through STM and reported that they were able to provide more effective care to their patients.
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