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  Indian J Med Microbiol
 

Figure 4: The spatial distribution of nuclear size can be used as a guide to assist pathologists in locating regions of interest. (a) A low magnification overview of a Grade IV clear cell renal cell carcinoma is annotated using a red contour (H&E stain). (b) The spatial distribution of nuclear size can be used to locate high-grade regions (red) as well as necrosis regions (blue).c) The high-grade region (located at the + mark) shows tumor cells with enlarged and pleomorphic nuclei and a prominent nucleolus. (d) This necrosis region can also be located at the + mark on the distribution image (inset)

Figure 4: The spatial distribution of nuclear size can be used as a guide to assist pathologists in locating regions of interest. (a) A low magnification overview of a Grade IV clear cell renal cell carcinoma is annotated using a red contour (H&E stain). (b) The spatial distribution of nuclear size can be used to locate high-grade regions (red) as well as necrosis regions (blue).c) The high-grade region (located at the + mark) shows tumor cells with enlarged and pleomorphic nuclei and a prominent nucleolus. (d) This necrosis region can also be located at the + mark on the distribution image (inset)