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  Indian J Med Microbiol
 

Figure 5: A pathologists' computer assisted diagnosis (pCAD) system organizes images of lymph node fragments into a series of well triaged regions of interests (ROIs) that are ready for rapid pathologist review. At top are the lymph node fragments, displayed in order from largest to smallest, without regard to the source WSIs (i.e., neighboring fragments may not be from the same WSI or slide). Through a series of image analysis and anatomic rules, the pCAD system subdivides the imaged fragments into clinically relevant ROIs (not shown in detail but depicted by the vertical blue arrow). For the specific work task of finding tumor metastases, the ROIs are triaged or sorted for pathologist review, from most-suspicious (left) to least (right). The riskiest, left-most ROI is a subcapsular sinus image that contains a small tumor metastasis that is highlighted by a red dot. Remaining ROIs are benign appearing, but are still sorted by other factors, including lymph node compartment, surgical designation, etc. Note that the least suspicious peri-nodal fat ROIs are off to the right; such ROIs could be reviewed last, rapidly (i.e., low magnification), or perhaps not at all if the pCAD system were clinically trustworthy

Figure 5: A pathologists' computer assisted diagnosis (pCAD) system organizes images of lymph node fragments into a series of well triaged regions of interests (ROIs) that are ready for rapid pathologist review. At top are the lymph node fragments, displayed in order from largest to smallest, without regard to the source WSIs (i.e., neighboring fragments may not be from the same WSI or slide). Through a series of image analysis and anatomic rules, the pCAD system subdivides the imaged fragments into clinically relevant ROIs (not shown in detail but depicted by the vertical blue arrow). For the specific work task of finding tumor metastases, the ROIs are triaged or sorted for pathologist review, from most-suspicious (left) to least (right). The riskiest, left-most ROI is a subcapsular sinus image that contains a small tumor metastasis that is highlighted by a red dot. Remaining ROIs are benign appearing, but are still sorted by other factors, including lymph node compartment, surgical designation, etc. Note that the least suspicious peri-nodal fat ROIs are off to the right; such ROIs could be reviewed last, rapidly (i.e., low magnification), or perhaps not at all if the pCAD system were clinically trustworthy