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  Indian J Med Microbiol
 

Figure 6: A case for which there was debate primarily concerning carcinosarcoma versus high-grade serous but also some consideration of endometrioid differentiation. (a and b) In one slide containing glandular epithelial elements displaying notable nuclear atypia and surrounding desmoplastic stroma, there was no section-based consensus, as this was assessed as endometrioid by one observer, as carcinosarcoma by the second, and as high-grade serous by the third. (c and d) In another slide, the section-based consensus (2/3) was high-grade serous, with one observer diagnosing carcinosarcoma. These discrepancies can be attributed to the observation that both sections were dominated by glandular elements within desmoplastic stroma as seen in a and b, but small regions with cytologically malignant spindled stroma were present. The case-based consensus (2/3) interpretation was carcinosarcoma, with the minority diagnosis of high-grade serous carcinoma attributable to failure to identify or place less importance on the presence of the small foci with a malignant mesenchymal component

Figure 6: A case for which there was debate primarily concerning carcinosarcoma versus high-grade serous but also some consideration of endometrioid differentiation. (a and b) In one slide containing glandular epithelial elements displaying notable nuclear atypia and surrounding desmoplastic stroma, there was no section-based consensus, as this was assessed as endometrioid by one observer, as carcinosarcoma by the second, and as high-grade serous by the third. (c and d) In another slide, the section-based consensus (2/3) was high-grade serous, with one observer diagnosing carcinosarcoma. These discrepancies can be attributed to the observation that both sections were dominated by glandular elements within desmoplastic stroma as seen in a and b, but small regions with cytologically malignant spindled stroma were present. The case-based consensus (2/3) interpretation was carcinosarcoma, with the minority diagnosis of high-grade serous carcinoma attributable to failure to identify or place less importance on the presence of the small foci with a malignant mesenchymal component