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  Indian J Med Microbiol
 

Figure 5: Image patches from case 12, the only misclassified case in the study. There are multiple cells with nondescript, bizarre shapes and hyperchromatic nuclei (red arrows). In practice, the presence of these cells, even in the absence of other worrisome features, would significantly raise the level of the pathologists' concern about a high-grade malignancy. Some of the cells in (c and d) appear to have two nuclei. (e and f) Captured from a different area of the whole slide image, demonstrate a strikingly different morphology, with a distinct population of cells displaying less hyperchromatic nuclei with discernible nucleoli. Some of the cells appear merged together, forming giant cells with a somewhat syncytial appearance (green arrows) (H&E). The image patches in each panel are 512 pixels × 512 pixels and approximately correspond to × 200 magnification

Figure 5: Image patches from case 12, the only misclassified case in the study. There are multiple cells with nondescript, <i>bizarre</i> shapes and hyperchromatic nuclei (red arrows). In practice, the presence of these cells, even in the absence of other worrisome features, would significantly raise the level of the pathologists' concern about a high-grade malignancy. Some of the cells in (c and d) appear to have two nuclei. (e and f) Captured from a different area of the whole slide image, demonstrate a strikingly different morphology, with a distinct population of cells displaying less hyperchromatic nuclei with discernible nucleoli. Some of the cells appear merged together, forming giant cells with a somewhat <i>syncytial</i> appearance (green arrows) (H&E). The image patches in each panel are 512 pixels × 512 pixels and approximately correspond to × 200 magnification