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  Indian J Med Microbiol
 

Figure 1: Methods for the assessment of intratumor heterogeneity. (a) Feature plot, tumor bud; green, CD3+; blue, CD8+; red, tumor core; yellow and invasive margin; teal. (b) Tiled Whole Slide Image (WSI). (c) Getis-Ord analysis: Tiles of interest overlaid in red and neighboring tiles overlaid in yellow. (d) Getis-Ord analysis: Detection of CD3 + cell hotspots in the invasive margin and tumor core, CD3+; blue and hotspot tile; red. (e) Heatmap analysis: Heatmap generation for CD3 + cells in the invasive margin and tumor core shows a spectrum through yellow (high CD3+) to black (low CD3+). (f) Heatmap analysis: Categorization of cold and hotspots within the WSI, hot tiles in red and cold tiles in blue

Figure 1: Methods for the assessment of intratumor heterogeneity. (a) Feature plot, tumor bud; green, CD3<sup>+</sup>; blue, CD8<sup>+</sup>; red, tumor core; yellow and invasive margin; teal. (b) Tiled Whole Slide Image (WSI). (c) Getis-Ord analysis: Tiles of interest overlaid in red and neighboring tiles overlaid in yellow. (d) Getis-Ord analysis: Detection of CD3<sup> +</sup> cell hotspots in the invasive margin and tumor core, CD3<sup>+</sup>; blue and hotspot tile; red. (e) Heatmap analysis: Heatmap generation for CD3<sup> +</sup> cells in the invasive margin and tumor core shows a spectrum through yellow (high CD3<sup>+</sup>) to black (low CD3<sup>+</sup>). (f) Heatmap analysis: Categorization of cold and hotspots within the WSI, hot tiles in red and cold tiles in blue